rho-7

Symbol: rho-7
Name: rhomboid-7
Entrez gene ID: 36281
Ensembl gene ID: FBgn0033672
Species: Fly (Taxid: 7227)

Functional description:
Required for mitochondrial fusion during fly spermatogenesis and muscle maturation; rhomboid-7; rhomboid-7 [Source:FlyBase gene name;Acc:FBgn0033672] [Ensembl]; The gene rhomboid-7 is referred to in FlyBase by the symbol Dmel\rho-7 (CG8972, FBgn0033672). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: serine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process: mitochondrial fusion. 6 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; Nebenkern; testis; eye photoreceptor cell; mitochondrion; seminal vesicle; indirect flight muscle; spermatozoon. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase S54, rhomboid; Peptidase S54, rhomboid domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed in adult male stages. [FlyBase]

Observation:

rho-7 knockout flies have severe neurological defects and a much reduced lifespan [16713954].



Interventions:
  • rho-7 knockout

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Type:
  • Gene
  • Protein coding

    References:
  • 16713954: Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PARL (9606)
  • PARL (9598)
  • PARL (9615)
  • PARL (9913)
  • Parl (10090)
  • Parl (10116)
  • PARL (9031)
  • LOC792889 (7955)
  • rho-7 (7227)
  • AgaP_AGAP002626 (7165)

  • Inparanoids
  • FBpp0087151 (7227)
  • ENSMUSP00000045361 (10090)
  • ENSRNOP00000029124 (10116)
  • ENSMMUP00000026065 (9544)
  • ENSP00000325421 (9606)
  • YGR101W (4932)
  • SPBC13E7.11 (4896)



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