Denigma

RAD27

Symbol: RAD27
Entrez gene ID: 853747
Ensembl gene ID: YKL113C
Species: Yeast (Taxid: 4932)

Functional description:
Rad27p; 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family [Source:SGD;Acc:S000001596] [Ensembl]

Observation:

Deletion of RAD27 results in signs of premature aging and approximately 60% reduction in mean replicative lifespan [12024027].



Interventions:
  • RAD27 deletion -60%

    • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • FEN1 (9606)
  • FEN1 (9598)
  • FEN1 (9615)
  • FEN1 (9913)
  • Fen1 (10090)
  • Fen1 (10116)
  • FEN1 (9031)
  • Fen1 (7227)
  • AgaP_AGAP011448 (7165)
  • crn-1 (6239)
  • rad2 (4896)
  • RAD27 (4932)
  • KLLA0F02992g (28985)
  • GeneID:2676517 (148305)
  • NCU10776 (5141)
  • AT5G26680 (3702)
  • Os05g0540100 (4530)
  • FEN-1 (5833)



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