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Symbol: rab-7 Name: RAB family Entrez gene ID: 174834 Ensembl gene ID: W03C9.3 Species: Worm (Taxid: 6239) Functional description: Protein RAB-7; RAB family member (rab-7) [Source:RefSeq peptide;Acc:NP_496549] [Ensembl]; rab-7 encodes a Rab GTPase orthologous to the Rab7 GTPases of yeast, Drosophila, and vertebrates; RAB-7 is required for endosome and endosome to lysosome trafficking and thus, for proper yolk protein transport in oocytes and transport of endocytosed materials in coelomoyctes; RAB-7 is also required for apoptotic cell clearance, particularly for regulation of lysosome to phagosome fusion; RAB-7 activity is also required for normal embryogenesis, locomotion, and body morphology; RAB-7 localizes to late endosomes, lysosomes, and phagosomes; RAB-7 localization, and presumably function, at endosomes is positively regulated by SAND-1, a novel, conserved protein required for early to late endosome maturation and transport; rab-7 activity is upregulated by tub-1/tubby, a gene involved in obesity across species, suggesting that rab-7 may also be involved in a tub-1/tubby mediated endocytic pathway for regulation of fat storage. [WormBase] Observation: RNA interference decreased median lifespan by 32% in wild type animals, 48% in a daf-2 background and 18% in daf-2/daf-16 double mutants. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Edit \ Update (Admin) | Delete |
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