puc

Symbol: puc
Name: puckered
Entrez gene ID: 40958
Ensembl gene ID: FBgn0243512
Species: Fly (Taxid: 7227)

Functional description:
JNK-specific phosphatase that downregulates the JNK pathway [9472024]; puckered; puckered [Source:FlyBase gene name;Acc:FBgn0243512] [Ensembl]; The gene puckered is referred to in FlyBase by the symbol Dmel\puc (CG7850, FBgn0243512). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: JUN kinase phosphatase activity; phosphoprotein phosphatase activity. There is experimental evidence for 21 unique biological process terms, many of which group under: cellular component organization or biogenesis; biological regulation; ovarian follicle cell development; multicellular organismal development; system development; localization; post-embryonic organ morphogenesis; response to stress; multicellular organism reproduction; instar larval or pupal morphogenesis; actin filament-based process. 59 alleles are reported. The phenotypes of these alleles are annotated with 30 unique terms, many of which group under: organ system; organ system subdivision; acellular anatomical structure; external compound sense organ; adult segment; non-connected developing system; imaginal precursor; peripheral nervous system; portion of tissue; embryonic dorsal vessel. It has one annotated transcript and one annotated polypeptide. Protein features are: Dual specificity phosphatase; Dual specificity phosphatase, catalytic domain; Dual specificity phosphatase, subgroup, catalytic domain; Protein-tyrosine phosphatase, active site; Protein-tyrosine/Dual-specificity phosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 12-24 hour embryonic stages, during late larval stages, during early pupal stages. [FlyBase]

Observation:

Heterozygous loss-of-function mutations in puc (either pucA241.1 or pucE69) significantly extend median and maximum lifespan and increase resistance to oxidative stress. Heterzyogosity for puc only modestly extends lifespan in animals carrying a hypomorphic allele of the JNK kinase hep [14602080].

puc heterzyogotes do not differ signficantly from wild-type for body size, reproductive activity or developmental timing, but exhibit increased resistance to oxidative stress and starvation [14602080].



Interventions:
  • puc mutation

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • References:
  • 14602080: JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • puc (7227)
  • AgaP_AGAP004353 (7165)

  • Inparanoids
  • FBpp0081288 (7227)
  • ENSMUSP00000049414 (10090)
  • ENSRNOP00000005400 (10116)
  • ENSP00000380530 (9606)



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