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Symbol: prx-5 Name: PeRoXisome assembly factor Entrez gene ID: 174392 Ensembl gene ID: C34C6.6 Species: Worm (Taxid: 6239) Functional description: Protein PRX-5; PeRoXisome assembly factor family member (prx-5) [Source:RefSeq peptide;Acc:NP_001022019] [Ensembl]; prx-5 encodes an ortholog of the human receptor for type I peroxisomal targeting signal protein, PXR1 (or PEX5; OMIM:600414), which when mutated leads to neonatal adrenoleukodystrophy or Zellweger syndrome; PXR1 protein is a component of the peroxisomal import machinery known to exist in organisms like yeast, plants and mammals. Peroxisomal diseases in humans often lead to degeneration or poor development of neurons; for example, Zellweger Syndrome represents a class of peroxisomal biogenesis disorders in which the entire peroxisomal compartment is compromised and is associated with severe neurological impairments. PRX-5 protein interacts strongly in a two-hybrid assay with Gal4p-SKL, indicating that the eukaryotic PRX5-dependent route for importing PTS1-containing proteins into peroxisomes is conserved in nematodes; furthermore, a screen using PRX-5 identified interaction partners which appear likely to be peroxisomal proteins. [WormBase] Observation: Postdevelopmental RNAi kockdown of prx-5 in the enhanced RNAi strain eri-1(mg366) increases mean lifespan by 30% [17411345]. Knockdown of prx-5 initiated on the first day of adulthood increases mean and maximum lifespan by 8% (6%!) and 11% respectively. prx-5 knockdown from hatching has no effect on lifespan or slightly shortened lifespan [22509016]. This might indicate that prx-5 is important during development but may exert postedevelopmental detrimental effects on longevity [22509016]. Interventions: Assays: Organismal Lifespan Mean: +8-30 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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