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Symbol: Ppm1d Name: protein phosphatase 1D magnesium-dependent, delta isoform Entrez gene ID: 53892 Ensembl gene ID: ENSMUSG00000020525 Species: Mouse (Taxid: 10090) Functional description: Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-18' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (By similarity). [UniProt] Observation: Knockout mice are resistant to spontaneous tumors but show a modest reduction in lifespan and reduced body weight. Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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