Polg

Symbol: Polg
Name: Polymerase (DNA directed), gamma
Entrez gene ID: 18975
Ensembl gene ID: ENSMUSG00000039176
Species: Mouse (Taxid: 10090)

Functional description:
polymerase (DNA directed), gamma; polymerase (DNA directed), gamma [Source:MGI Symbol;Acc:MGI:1196389] [Ensembl]

Observation:

Mice with a proof-reading-deficient version of Polg display an increased amount of mtDNA mutations (by 3 to 5-fold) and signs of premature ageing including a reduced lifespan, weight loss, reduced subcutaneous fat, alopecia, kyphosis, osteoporosis, anaemia, reduced fertility, and heart enlargement. Median lifespan of homozyous Polg mutant knock-in mice is 48 months [15164064].



Interventions:
  • Homozygous knock-in of proof-reading deficient Polg

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • POLG (9606)
  • POLG (9598)
  • POLG (9615)
  • Polg (10090)
  • Polg (10116)
  • POLG (9031)
  • LOC560613 (7955)
  • LOC100150924 (7955)
  • tam (7227)
  • AgaP_AGAP000139 (7165)
  • pog1 (4896)
  • MIP1 (4932)
  • KLLA0F02574g (28985)
  • AGOS_ADR357C (33169)
  • GeneID:2679899 (148305)
  • NCU00276 (5141)



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