Bub3

Symbol: Bub3
Name: budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae)
Entrez gene ID: 12237
Ensembl gene ID: ENSMUSG00000066979
Species: Mouse (Taxid: 10090)

Functional description:
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity). Regulates chromosome segregation during oocyte meiosis. [UniProt]

Observation:

Haploinsufficiency of Bub3 and Rae1, but not haploinsufficiency of either gene by itself, reduces lifespan by 12% and appears to accelerate aging [16476774].



Interventions:
  • Bub3 and Rae1 haploinsuficiency -12%

  • Assays: Organismal Lifespan

    Classification:
  • Aging Associated


  • References:
  • 16476774: Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • BUB3 (9606)
  • BUB3 (9598)
  • BUB3 (9615)
  • BUB3 (9913)
  • Bub3 (10090)
  • BUB3 (9031)
  • bub3 (7955)
  • Bub3 (7227)
  • AgaP_AGAP010544 (7165)
  • bub3 (4896)
  • AT1G49910 (3702)
  • AT3G19590 (3702)
  • Os03g0448600 (4530)

  • Inparanoids
  • ENSMUSP00000081547 (10090)
  • SPAC23H3.08c (4896)
  • ENSMUSP00000081547 (10090)
  • ENSMUSP00000081547 (10090)
  • ENSMUSP00000081547 (10090)



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