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Symbol: Pka-C1 Name: cAMP-dependent protein kinase 1 Entrez gene ID: 34284 Ensembl gene ID: FBgn0000273 Species: Fly (Taxid: 7227) Functional description: cAMP-dependent protein kinase 1; cAMP-dependent protein kinase 1 [Source:FlyBase gene name;Acc:FBgn0000273] [Ensembl]; The gene cAMP-dependent protein kinase 1 is referred to in FlyBase by the symbol Dmel\Pka-C1 (CG4379, FBgn0000273). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 15 unique biological process terms, many of which group under: biological regulation; anatomical structure development; cellular process involved in reproduction; multicellular organismal reproductive process; learning or memory; regulation of response to stimulus; regulation of multicellular organismal development; rhythmic process; macromolecule modification; regulation of developmental process; memory. 88 alleles are reported. The phenotypes of these alleles are annotated with 33 unique terms, many of which group under: organ system subdivision; adult segment; organ system; external compound sense organ; female germline cyst; adult mesothoracic segment; nervous system; imaginal precursor; egg; dorsal thoracic disc; synapse; epithelial furrow; antennal segment. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: AGC-kinase, C-terminal; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual-specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during late pupal stages. [FlyBase] Observation: PKA-overexpressing flies (hsPKA*/+) have an about 30% extended maximum lifespan [17369827]. Assays: Organismal Lifespan Maximum: +30 Classification: Type: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Edit \ Update (Admin) | Delete |
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