Pck1

Symbol: Pck1
Name: phosphoenolpyruvate carboxykinase 1, cytosolic
Alias: PEPCK
Entrez gene ID: 18534
Ensembl gene ID: ENSMUSG00000027513
Species: Mouse (Taxid: 10090)

Functional description:
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity). [UniProt]

Observation:

Overexpression of Pck1 in skeletal muscle results in an increased number of mitochondria, markedly increase in activity, and extended lifespan by 30%. Transgenic mice ate 60% more than controls but had half the body weight and 10% of the body fat [17716967; Hakimi, Berger and Hanson, unpublished]. Pck1 overxpression leads to increased storage and utilization of fatty acids in muscle for energy purposes and mutants store up to 5-times more triglyceride in their skeletal muscle, and exhibit increased levels of physiological activity [18394430].



Interventions:
  • Pck1 overxpression +30%

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PCK1 (9606)
  • PCK1 (9598)
  • PCK1 (9615)
  • PCK1 (9913)
  • Pck1 (10090)
  • Pck1 (10116)
  • PCK1 (9031)
  • pck1 (7955)
  • CG10924 (7227)

  • Inparanoids
  • ENSRNOP00000030913 (10116)
  • ENSMUSP00000029017 (10090)
  • ENSMUSP00000029017 (10090)



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