Pawr

Symbol: Pawr
Name: PRKC, apoptosis, WT1, regulator
Entrez gene ID: 114774
Ensembl gene ID: ENSMUSG00000035873
Species: Mouse (Taxid: 10090)

Functional description:
Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity). [UniProt]

Observation:

Mice overexpressing the pro-apoptotic protein domain were resistant to tumours. Transgenic animals showed normal fertility, viability, and ageing, though they were slightly longer-lived possibly because of the cancer-resistance.



Assays: Organismal Lifespan

Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PAWR (9606)
  • PAWR (9598)
  • PAWR (9913)
  • Pawr (10090)
  • Pawr (10116)
  • PAWR (9031)
  • pawrl (7955)

  • Inparanoids
  • ENSRNOP00000008222 (10116)
  • ENSMUSP00000092951 (10090)
  • ENSMUSP00000092951 (10090)



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