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Symbol: pat-4 Name: Paralysed Arrest at Two-fold Entrez gene ID: 175175 Ensembl gene ID: C29F9.7 Species: Worm (Taxid: 6239) Functional description: Protein PAT-4; Paralysed Arrest at Two-fold family member (pat-4) [Source:RefSeq peptide;Acc:NP_497139] [Ensembl]; The pat-4 gene encodes a serine/threonine kinase orthologous to human integrin-linked kinase (ILK, OMIM:602366) and is required for formation of integrin-mediated muscle cell attachments during embryogenesis; PAT-4 probably functions as an adaptor molecule and localizes to dense bodies and M lines; PAT-4 forms a ternary complex with PAT-6/actopaxin and UNC-112, and requires UNC-112, UNC-52/perlecan, PAT-2/alpha integrin, and PAT-3/beta integrin for proper localization to newly forming integrin adhesion complexes. [WormBase] Observation: RNA interference increased mean lifespan by 9-16%. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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