Pappa

Symbol: Pappa
Name: Pregnancy-associated plasma protein A
Entrez gene ID: 18491
Ensembl gene ID: ENSMUSG00000028370
Species: Mouse (Taxid: 10090)

Functional description:
Could be involved in local cell proliferative processes; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected. [UniProt]

Observation:

Genetic deletion of PAPPA extended mean and maximum lifespan by 30-40% and reduced cancer incidence with no reduction in food intake or secondary endocrine abnormalities.



Assays: Organismal Lifespan

Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PAPPA (9606)
  • PAPPA (9615)
  • PAPPA (9913)
  • Pappa (10090)
  • Pappa (10116)
  • PAPPA (9031)
  • LOC100004323 (7955)
  • LOC566095 (7955)
  • LOC100334228 (7955)



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