Denigma

nuc-1

Symbol: nuc-1
Name: abnormal NUClease
Entrez gene ID: 181174
Ensembl gene ID: C07B5.5
Species: Worm (Taxid: 6239)

Functional description:
Deoxyribonuclease II, involved in apoptotic DNA degradation [12718884]; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Implicated in apoptosis. [UniProt]

Observation:

RNA interference of nuc-1 extends mean lifespan by 30%. nuc-1 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331].

nuc-1 null mutants display reduced fertility [11861554].



Interventions:
  • nuc-1 RNAi +30%

    • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • DNASE2 (9606)
  • DNASE2 (9598)
  • DNASE2 (9615)
  • DNASE2 (9913)
  • Dnase2a (10090)
  • Dnase2a (10116)
  • dnase2 (7955)
  • DNaseII (7227)
  • AgaP_AGAP003295 (7165)
  • crn-6 (6239)
  • tag-198 (6239)
  • nuc-1 (6239)



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