nrx-1

Symbol: nrx-1
Name: GLIoTactin (Drosophila neuroligin-like) homolog
Entrez gene ID: 179503
Ensembl gene ID: C29A12.4
Species: Worm (Taxid: 6239)

Functional description:
Protein NRX-1; GLIoTactin (Drosophila neuroligin-like) homolog family member (nrx-1) [Source:RefSeq peptide;Acc:NP_505767] [Ensembl]; nrx-1 encodes the C. elegans ortholog of neurexins, presynaptic transmembrane neural adhesion molecules that contain extracellular laminin and EGF domains and play a critical role in synaptic development; genetic analyses suggest that nrx-1 may play a role in regulation of adult lifespan; nrx-1 expression is controlled by daf-2 and daf-16. [WormBase]

Observation:

Mutation reduced maximum lifespan by 40%.



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • NRXN3 (9598)
  • NRXN3 (9615)
  • Nrxn3 (10090)
  • Nrxn3 (10116)
  • NRXN3 (9031)
  • nrxn3a (7955)
  • LOC100332109 (7955)
  • nrxn3b (7955)
  • Nrx-1 (7227)
  • AgaP_AGAP004066 (7165)
  • nrx-1 (6239)



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