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Symbol: Nos3 Name: nitric oxide synthase 3, endothelial cell Entrez gene ID: 18127 Ensembl gene ID: ENSMUSG00000028978 Species: Mouse (Taxid: 10090) Functional description: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. May play a significant role in normal and abnormal limb development. [UniProt] Observation: Knockout males exhibited premature death and age-related cardiac dysfunction but not females. Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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