Denigma

mys

Symbol: mys
Name: myospheroid
Entrez gene ID: 44885
Ensembl gene ID: FBgn0004657
Species: Fly (Taxid: 7227)

Functional description:
Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig (Tiggrin). Also binds to wb (wing blister) and Ten-m (Tenascin major). Required for many embryonic (dorsal closure and somatic muscle attachments) and post-embryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development). Involved in the function and/or development of the olfactory system. [UniProt]

Observation:

mys mutants exhibit ameliorated age-related declines in locomotor activity and an increase in mean lifespan of 20% [14570233].



Interventions:
  • mys Mutation +20%

    • Assays: Organismal Lifespan
    Mean: +20

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


    • Type:
  • Gene
  • Protein coding

    References:
  • 14570233: Delayed behavioural aging and altered mortality in Drosophila beta integrin mutants.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • ITGB1 (9606)
  • ITGB1 (9598)
  • ITGB1 (9615)
  • ITGB1 (9913)
  • Itgb1 (10090)
  • Itgb1 (10116)
  • ITGB1 (9031)
  • itgb1a (7955)
  • itgb1b (7955)
  • mys (7227)
  • INTB (7165)
  • pat-3 (6239)

    • Inparanoids
  • FBpp0071061 (7227)
  • ENSMUSP00000087457 (10090)
  • ENSRNOP00000014785 (10116)
  • ENSMMUP00000004380 (9544)
  • ENSP00000364094 (9606)



    • Edit \ Update (Admin) | Delete

    Comment on This Data Unit