Denigma

Msra

Symbol: Msra
Name: Methionine sulfoxide reductase A
Entrez gene ID: 110265
Ensembl gene ID: ENSMUSG00000054733
Species: Mouse (Taxid: 10090)

Functional description:
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity). [UniProt]

Observation:

Msra homozygous knockouts exhibit a 40% shorter lifespan than wild-type or heterozygotes (C57BL/6J). Msra -/- mice have enhanced sensitivity to oxidative stress, accumulatehigher levels of protein cabronyls, and demonstrate and atypical walking pattern [11606777].



Interventions:
  • Msra knockout -40%

    • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • MSRA (9606)
  • MSRA (9598)
  • MSRA (9615)
  • MSRA (9913)
  • Msra (10090)
  • Msra (10116)
  • MSRA (9031)
  • si:dkey-221h15.1 (7955)
  • SPAC29E6.05c (4896)
  • MXR1 (4932)
  • KLLA0A01309g (28985)
  • GeneID:2677517 (148305)
  • NCU10029 (5141)
  • AT4G25130 (3702)
  • Os10g0563600 (4530)

    • Inparanoids
  • ENSMUSP00000065754 (10090)
  • ENSRNOP00000016616 (10116)
  • YER042W (4932)
  • SPAC29E6.05c (4896)
  • ENSMUSP00000065754 (10090)
  • ENSMUSP00000065754 (10090)
  • ENSMUSP00000065754 (10090)



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