Symbol: mrp-5 Name: Multidrug Resistance Protein family Entrez gene ID: 181587 Ensembl gene ID: F14F4.3 Species: Worm (Taxid: 6239) Functional description: Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily; Protein MRP-5; Multidrug Resistance Protein family member (mrp-5) [Source:RefSeq peptide;Acc:NP_510478] [Ensembl]; The mrp-5 gene encodes a homolog of the human gene CFTR, which when mutated leads to cystic fibrosis (OMIM:219700). The MRP-5A and MRP-5B proteins are predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. [WormBase] Observation: RNA interference of mrp-5 extends lifespan by 38%. mrp-5 RNAi also results in increased dauer formation and slow growth [12447374]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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