mrp-5

Symbol: mrp-5
Name: Multidrug Resistance Protein family
Entrez gene ID: 181587
Ensembl gene ID: F14F4.3
Species: Worm (Taxid: 6239)

Functional description:
Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily; Protein MRP-5; Multidrug Resistance Protein family member (mrp-5) [Source:RefSeq peptide;Acc:NP_510478] [Ensembl]; The mrp-5 gene encodes a homolog of the human gene CFTR, which when mutated leads to cystic fibrosis (OMIM:219700). The MRP-5A and MRP-5B proteins are predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. [WormBase]

Observation:

RNA interference of mrp-5 extends lifespan by 38%. mrp-5 RNAi also results in increased dauer formation and slow growth [12447374].



Interventions:
  • mrp-5 RNAi +38%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ABCC5 (9606)
  • ABCC5 (9615)
  • Abcc5 (10090)
  • Abcc5 (10116)
  • ABCC5 (9031)
  • si:ch1073-183g13.2 (7955)
  • mrp-5 (6239)



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