MPT5

Symbol: MPT5
Alias: UTH4
Entrez gene ID: 852697
Ensembl gene ID: YGL178W
Species: Yeast (Taxid: 4932)

Functional description:
Mpt5p; Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest [Source:SGD;Acc:S000003146] [Ensembl]; mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity [SGD]

Observation:

Overexpression of MPT5 from the ADH promoter extends replicative lifespan by about 20% in W303R [11805047] and by 25% in PSY142 [9150138], whereas the deletion of MPT5 shortens lifespan by about 50% [9150138; 7859289]. MPT5 deletion decreases average chronological lifespan by 50%, which is rescued to the wild-type level by PKC1 overexpression [17172436].

MPT5 mutants are temperature sensitive [7845352], hypersensitive to mating pheromone [9154842], and null mutants exhibit increased silencing at telomeres and decreased rDNA silencing [9584615]. Deletion of MPT5 is synthetical lethal with mutation of either SWI4, SWI6, or CCR4 in an ssd1-d background [11805047]. MPT5 overexpression suppresses the temperature phenotype of POP2 mutant [9504907]. MPT5 is required for relocalization of the SIR complex to the nucleolus in sir4-42 strain [7859289].



Interventions:
  • MPT5 deletion -50%
  • MPT5 overexpression +20 to +25%

  • Assays: Replicative Lifespan Chronological Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Positive Aging-Suppressor


  • References:
  • 7859289: Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae.
  • 9150138: Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • MPT5 (4932)
  • KLLA0E13597g (28985)
  • AGOS_ADL056W (33169)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit