Symbol: mec-8 Name: MEChanosensory abnormality Entrez gene ID: 172771 Ensembl gene ID: F46A9.6 Species: Worm (Taxid: 6239) Functional description: Protein MEC-8; MEChanosensory abnormality family member (mec-8) [Source:RefSeq peptide;Acc:NP_492508] [Ensembl]; mec-8 encodes a protein with two RNA recognition motifs (RRM); mec-8 is required for proper development of body wall muscle and chemosensory and touch receptor neurons and as a result, for embryonic and larval development, sensory neuron fasciculation, and mechanosensation; MEC-8 functions as an mRNA processing factor whose activity is required for alternative splicing of genes such as unc-52/perlecan, with which it interacts genetically to produce synthetic lethality at the two-fold stage of embryonic elongation; mec-8 mutations also exhibit synthetic lethality with mutations in a number of other genes, including the sym genes and daf-18; mec-8; unc-52 synthetic lethality is suppressed by mutations in smu-1 and smu-2 which both encode homologs of mammalian spliceosome-associated proteins; mec-8 is broadly expressed in the embryo and expressed in hypodermal and neuronal tissues in larvae. [WormBase] Observation: Recessive loss of function allele in mec-8 extends lifespan [10617200]. mec-8 mutations are mechanosensory defective and have defective dye filling of sensory neurons [8625846]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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