mdh-1

Symbol: mdh-1
Name: Malate DeHydrogenase
Entrez gene ID: 175936
Ensembl gene ID: F20H11.3
Species: Worm (Taxid: 6239)

Functional description:
Protein MDH-2; Protein F38B7.3 [Source:UniProtKB/TrEMBL;Acc:Q20151] [Ensembl]

Observation:

RNAi against mdh-1 decreases median lifespan by 10% in wild type animals and by 16% in daf-2 mutants [18006689]. mdh-1 RNAi started after the animal reached the late L4 stage increases mean and maximum lifespan by 4-27% and 9% [22103665].



Interventions:
  • mdh-1 RNAi +4 to +27% -10% +9%

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • MDH2 (9606)
  • MDH2 (9598)
  • MDH2 (9615)
  • Mdh2 (10090)
  • Mdh2 (10116)
  • MDH2 (9031)
  • zgc:64133 (7955)
  • CG7998 (7227)
  • AgaP_AGAP001903 (7165)
  • mdh-1 (6239)
  • SPCC306.08c (4896)
  • MDH1 (4932)
  • KLLA0F25960g (28985)
  • GeneID:2680415 (148305)
  • NCU04899 (5141)
  • AT1G53240 (3702)
  • AT3G15020 (3702)
  • Os01g0649100 (4530)
  • Os05g0574400 (4530)

  • Orthologs
  • MDH1 (4932)
  • MDH1 (4932)

  • Note: Discripance!

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