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Symbol: LYS12 Name: LYSine requiring 12 Alias: LYS10;LYS11 Entrez gene ID: 854714 Ensembl gene ID: YIL094C Species: Yeast (Taxid: 4932) Functional description: Lys12p; Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate [Source:SGD;Acc:S000001356] [Ensembl] Observation: Deletion of LYS12 extends mean replicative by 35% in the alpha strain but decreases mean replicative lifespan in the remade strain by 18% [16293764]. LYS12 deletion increases chronological lifespan [16418483]. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Note: Deletion of LYS12 extends mean replicative by 35% in the alpha strain but decreases mean replicative lifespan in the remade strain by 18% Edit \ Update (Admin) | Delete |
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