Denigma: Factor

lt

Symbol: lt
Name: light
Entrez gene ID: 3355130
Ensembl gene ID: FBgn0002566
Species: Fly (Taxid: 7227)

Functional description:
light; light [Source:FlyBase gene name;Acc:FBgn0002566] [Ensembl]; The gene light is referred to in FlyBase by the symbol Dmel\lt (CG18028, FBgn0002566). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding. There is experimental evidence that it is involved in the biological process: dsRNA transport; determination of adult lifespan; ommochrome biosynthetic process. 50 alleles are reported. The phenotypes of these alleles are annotated with: eye; Malpighian tubule; wing; ocellus pigment granule; pigment cell. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Clathrin, heavy chain/VPS, 7-fold repeat; Tetratricopeptide-like helical; Vacuolar protein sorting-associated protein 41; WD40 repeat; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40/YVTN repeat-like-containing domain; Zinc finger, RING-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period. [FlyBase]

Observation:

Loss-of-function mutation of lt reduces mean lifespan by 47% and maximum lifespan by 10% [17435236].

Interventions:

lt mutation -47% -10%

Assays: Organismal Lifespan
Mean: -47
Maximum: -10

Classification:

Aging-Suppressor

Negative Aging-Suppressor

References:

17435236: Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.

Aging Relevance Analysis/Source:

GenAge