Denigma

lin-23

Symbol: lin-23
Name: abnormal cell LINeage
Entrez gene ID: 174058
Ensembl gene ID: K10B2.1
Species: Worm (Taxid: 6239)

Functional description:
Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity). [UniProt]

Observation:

RNA interference shortened the extended lifespan of daf-2(mu150) mutants. Only a negligible or small reduction in the lifespan of wild-type worms was observed in knockouts.



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • FBXW11 (9606)
  • FBXW11 (9598)
  • FBXW11 (9615)
  • FBXW11 (9913)
  • Fbxw11 (10090)
  • Fbxw11 (10116)
  • FBXW11 (9031)
  • fbxw11a (7955)
  • fbxw11b (7955)
  • lin-23 (6239)
  • pof11 (4896)



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