KSS1

Symbol: KSS1
Name: Kinase Suppressor of Sst2 mutations 1
Entrez gene ID: 852931
Ensembl gene ID: YGR040W
Species: Yeast (Taxid: 4932)

Functional description:
Proliferation, differentiation, transcription regulation and development; Kss1p; Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains [Source:SGD;Acc:S000003272] [Ensembl]

Observation:

Deletion of KSS1 results in increased sensitivity to heat shock and oxidative stress and a 25% reduction in median chronological lifespan [17662940].



Interventions:
  • KSS1 deletion -25%

  • Assays: Chronological Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • MAPK1 (9606)
  • MAPK1 (9598)
  • MAPK1 (9615)
  • MAPK1 (9913)
  • Mapk1 (10090)
  • Mapk1 (10116)
  • MAPK1 (9031)
  • mapk1 (7955)
  • rl (7227)
  • AgaP_AGAP009207 (7165)
  • mpk-1 (6239)
  • KSS1 (4932)
  • KLLA0A02497g (28985)
  • AGOS_ACL191C (33169)
  • ATMPK13 (3702)
  • PfMAP1 (5833)



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