Symbol: InR Name: Insulin-like 1 receptor Entrez gene ID: 42549 Ensembl gene ID: FBgn0013984 Species: Fly (Taxid: 7227) Functional description: InR regulates cell growth and proliferation through the dP13K/dAkt pathway; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell- autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. [UniProt] Observation: Mutations in InR (InRE19/InRp5545 transheterozygous) result in dwarf females with extended lifespan of up to 85% and dwarf males with reduced late age-specific mortality (although no significant change in lifespan) [11292875]. InrGC25/InrE19 transheterozygous animals are short-lived an exhibit an elevated rate of age-independent mortality [11292874]. Natural allelic variation in InR are associated with variation in lifespan [15013662; 20074316]. Interventions: Assays: Organismal Lifespan Classification: References: Aging Relevance Analysis/Source: Homologs Orthologs Inparanoids Edit \ Update (Admin) | Delete |
Comment on This Data Unit