InR

Symbol: InR
Name: Insulin-like 1 receptor
Entrez gene ID: 42549
Ensembl gene ID: FBgn0013984
Species: Fly (Taxid: 7227)

Functional description:
InR regulates cell growth and proliferation through the dP13K/dAkt pathway; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell- autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. [UniProt]

Observation:

Mutations in InR (InRE19/InRp5545 transheterozygous) result in dwarf females with extended lifespan of up to 85% and dwarf males with reduced late age-specific mortality (although no significant change in lifespan) [11292875]. InrGC25/InrE19 transheterozygous animals are short-lived an exhibit an elevated rate of age-independent mortality [11292874].

Natural allelic variation in InR are associated with variation in lifespan [15013662; 20074316].



Interventions:
  • InRE19/InRp5545 transheterozygous mutation +85%
  • InrGC25/InrE19 transheterozygous mutation

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • Longevity-Associated


  • References:
  • 11292874: Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.
  • 11292875: A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.
  • 15013662: Quantitative trait loci affecting natural variation in Drosophila longevity.
  • 20074316: Identification of a candidate adaptive polymorphism for Drosophila life history by parallel independent clines on two continents.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • IGF1R (9606)
  • IGF1R (9598)
  • IGF1R (9615)
  • IGF1R (9913)
  • Igf1r (10090)
  • Igf1r (10116)
  • IGF1R (9031)
  • igf1ra (7955)
  • igf1rb (7955)
  • InR (7227)
  • INR (7165)
  • daf-2 (6239)

  • Orthologs
  • daf-2 (6239)
  • daf-2 (6239)

  • Inparanoids
  • FBpp0083519 (7227)
  • ENSMUSP00000005671 (10090)
  • ENSRNOP00000019267 (10116)
  • ENSMMUP00000016141 (9544)
  • ENSP00000268035 (9606)



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