Igf1r

Symbol: Igf1r
Name: Insulin-like growth factor 1 receptor
Alias: IGF-1R
Entrez gene ID: 16001
Ensembl gene ID: ENSMUSG00000005533
Species: Mouse (Taxid: 10090)

Functional description:
IGF1 receptor that mediates growth; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake (By similarity). [UniProt]

Observation:

Homozygous null mutation of Igf1r is lethal at birth [8402901]. Mice heterozygous for IGF1R live 26% longer. Female Igf1r(+/-) mice have 33% longer mean lifespan, whereas male mice exhibit an increase in mean lifespan of 16% (not statistically significant). Long-lived Igf1r+/- mice do not develop dwarfism, have normal energy metabolism, food and water intake, unaffected nutrient uptake, physical activity, glucose regulation, serum insulin and glucose, fertility and reproduction [12483226]. Heterozygous Igf1r mutants are more resistant to paraquat and mouse embryonic fibroblasts derived from them are more resistant to hydrogen peroxide [8402901].



Interventions:
  • Igf1r knockout +16 to 33%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • IGF1R (9606)
  • IGF1R (9598)
  • IGF1R (9615)
  • IGF1R (9913)
  • Igf1r (10090)
  • Igf1r (10116)
  • IGF1R (9031)
  • igf1ra (7955)
  • igf1rb (7955)
  • InR (7227)
  • INR (7165)
  • daf-2 (6239)

  • Orthologs
  • daf-2 (6239)
  • daf-2 (6239)

  • Inparanoids
  • ENSMUSP00000005671 (10090)
  • ENSRNOP00000019267 (10116)
  • ENSMUSP00000005671 (10090)
  • ENSMUSP00000005671 (10090)
  • ENSMUSP00000005671 (10090)



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