Denigma

iff-1

Symbol: iff-1
Name: Initiation Factor Five (eIF-5A) homologs
Entrez gene ID: 176373
Ensembl gene ID: T05G5.10
Species: Worm (Taxid: 6239)

Functional description:
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity). Required for mitotic germ cell proliferation, gametogenesis after entry into meiosis, and localization of the P granule component pgl-1 on P granules. [UniProt]

Observation:

RNA interference extended lifespan.



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • EIF5A2 (9606)
  • EIF5A2 (9598)
  • EIF5A2 (9615)
  • EIF5A2 (9913)
  • Eif5a2 (10090)
  • Eif5a2 (10116)
  • EIF5A2 (9031)
  • eif5a2 (7955)
  • eIF-5A (7227)
  • AgaP_AGAP011284 (7165)
  • iff-1 (6239)
  • iff-2 (6239)



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