IDH2

Symbol: IDH2
Name: Isocitrate DeHydrogenase 2
Entrez gene ID: 854303
Ensembl gene ID: YOR136W
Species: Yeast (Taxid: 4932)

Functional description:
Idh2p; Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated [Source:SGD;Acc:S000005662] [Ensembl]

Observation:

Deletion of IDH2 increases the mean replicative lifespan by about 30% [16293764]. IDH2 deletion extends mean replicative lifespan by 20% in the alpha strain and in a strain [19030232; 18340043]. IDH2 deletion extends mean, median and maximum lifespan by 5, 19 and 15% [23167605].



Interventions:
  • IDH2 deletion +15.4 to +30% +19.2% +15.4%

  • Assays: Replicative Lifespan
    Mean: +15.4 to +30
    Median: +19.2
    Maximum: +15.4

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • References:
  • 18340043: Quantitative evidence for conserved longevity pathways between divergent eukaryotic species.
  • 16293764: Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
  • 19030232: Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity.
  • 23167605: Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • IDH3A (9606)
  • IDH3A (9598)
  • IDH3A (9615)
  • IDH3A (9913)
  • Idh3a (10090)
  • Idh3a (10116)
  • IDH3A (9031)
  • idh3a (7955)
  • l(1)G0156 (7227)
  • AgaP_AGAP002728 (7165)
  • F43G9.1 (6239)
  • idh2 (4896)
  • IDH2 (4932)
  • KLLA0E03125g (28985)
  • AGOS_AFR137C (33169)
  • GeneID:2679352 (148305)
  • NCU07697 (5141)
  • AT5G03290 (3702)
  • AT3G09810 (3702)
  • Os01g0276100 (4530)



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