HXK2

Symbol: HXK2
Name: HeXoKinase 2
Alias: HEX1; SCI2; HKB
Entrez gene ID: 852639
Ensembl gene ID: YGL253W
Species: Yeast (Taxid: 4932)

Functional description:
Hxk2p; Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene [Source:SGD;Acc:S000003222] [Ensembl]

Observation:

Deletion of HXK2 extends mean and maximum replicative lifespan by about 53% and 33%, respectively. Limiting glucose availability by mutating HXK2 significantly extends replicative lifespan and provides a genetically model of DR [11000115]. HXK2 deletion increases oxygene consumption. Changes in gene expression HXK2 mutation are quite similar to those of dietary-restricted cells. In fact, HXK2 mutants have a transcriptional profile that significantly resembles DR cells and cell overexpressing HAP4 [12124627].



Interventions:
  • HXK2 deletion +53% +33%

  • Assays: Replicative Lifespan
    Mean: +53
    Maximum: +33

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • HK1 (9606)
  • HK1 (9598)
  • HK1 (9615)
  • HK1 (9913)
  • Hk1 (10090)
  • HK1 (9031)
  • hk1 (7955)
  • Hex-t2 (7227)
  • hxk1 (4896)
  • HXK1 (4932)
  • HXK2 (4932)
  • KLLA0D11352g (28985)
  • AGOS_AFR279C (33169)
  • GeneID:2680167 (148305)
  • NCU02542 (5141)
  • HXK2 (3702)
  • HXK1 (3702)
  • Os05g0522500 (4530)
  • Os01g0742500 (4530)

  • Orthologs
  • Hk1 (10090)
  • HK1 (9544)
  • HK1 (9606)
  • HK2 (9606)
  • HK3 (9606)
  • GCK (9544)
  • HKDC1 (9606)
  • hxk1 (4896)
  • Hk2 (10090)
  • HK3 (9544)
  • Hex-A (7227)
  • Gck (10090)
  • Hex-t2 (7227)
  • Y77E11A.1 (6239)
  • Hk3 (10090)
  • Gck (10116)
  • Hkdc1 (10090)
  • GCK (9606)
  • HKDC1 (9544)
  • hexokinase (6239)
  • Hexokinases (6239)
  • Hk2 (10116)
  • Hk3 (10116)
  • Hex-C (7227)
  • Hex-t1 (7227)
  • HK2 (9544)
  • Hk1 (10090)
  • HK1 (9544)
  • GLK1 (4932)
  • HK1 (9606)
  • HK2 (9606)
  • HK3 (9606)
  • EMI2 (4932)
  • GCK (9544)
  • HKDC1 (9606)
  • hxk1 (4896)
  • Hk2 (10090)
  • HK3 (9544)
  • Hex-A (7227)
  • Gck (10090)
  • HXK1 (4932)
  • Hex-t2 (7227)
  • Y77E11A.1 (6239)
  • Hk3 (10090)
  • Gck (10116)
  • Hkdc1 (10090)
  • GCK (9606)
  • HKDC1 (9544)
  • hexokinase (6239)
  • Hexokinases (6239)
  • Hk2 (10116)
  • Hk3 (10116)
  • Hex-C (7227)
  • Hex-t1 (7227)
  • HK2 (9544)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit