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Symbol: hus-1 Name: human HUS1 related Entrez gene ID: 171939 Ensembl gene ID: H26D21.1 Species: Worm (Taxid: 6239) Functional description: Protein HUS-1; human HUS1 related family member (hus-1) [Source:RefSeq peptide;Acc:NP_491203] [Ensembl]; hus-1 encodes the C. elegans ortholog of the Schizosaccharomyces pombe Hus1 DNA damage checkpoint protein; in C. elegans, hus-1 activity is required for DNA damage-induced cell cycle arrest and apoptosis, telomere maintenance, and hence, genome stability and development; specifically, hus-1 is required for the CEP-1/p53-dependent increase in germline egl-1 expression following irradiation; a HUS-1::GFP fusion protein is detected in the nuclei of mitotic and meiotic germ cells, mature oocytes, embryos, and somatic larval cells, particularly those that are proliferating; while HUS-1 localization is generally diffuse throughout these nuclei, following irradiation, HUS-1 localizes to discrete foci that overlap with chromatin; HUS-1 nuclear localization is dependent upon the Rad9 homologue HPR-9 and upon the checkpoint protein MRT-2, with which it interacts in yeast two-hybrid and in vitro assays. [WormBase] Observation: RNA interference increased mean lifespan by 11%. In hus-1 mutants, RNA interference of cep-1 did not increase lifespan, suggesting both genes influence lifespan through the same pathway. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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