Denigma

htr1b

Symbol: htr1b
Name: 5-hydroxytryptamine (serotonin) receptor 1B
Entrez gene ID: 15551
Ensembl gene ID: ENSMUSG00000049511
Species: Mouse (Taxid: 10090)

Functional description:
5-hydroxytryptamine (serotonin) receptor 1B; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. [UniProt]

Observation:

Knockout mice displayed a decreased lifespan and early age-related motor decline.



Assays: Organismal Lifespan

Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • HTR1B (9606)
  • HTR1B (9598)
  • HTR1B (9913)
  • Htr1b (10090)
  • Htr1b (10116)
  • HTR1B (9031)
  • LOC561647 (7955)
  • 5-HT7 (7227)
  • GPRNNA20 (7165)
  • GPR5HT7 (7165)

    • Inparanoids
  • ENSRNOP00000017411 (10116)
  • ENSMUSP00000050898 (10090)
  • ENSMUSP00000050898 (10090)
  • ENSMUSP00000050898 (10090)



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