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Symbol: Hsp70Bc Name: Heat-shock-protein-70Bb Entrez gene ID: 48582 Ensembl gene ID: FBgn0013278 Species: Fly (Taxid: 7227) Functional description: Heat shock protein 68; Heat shock protein 68 [Source:FlyBase gene name;Acc:FBgn0001230] [Ensembl]; The gene Heat shock protein 68 is referred to in FlyBase by the symbol Dmel\Hsp68 (CG5436, FBgn0001230). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: unfolded protein binding. There is experimental evidence that it is involved in the biological process: determination of adult lifespan; response to methotrexate; neurogenesis. 10 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Heat shock protein 70; Heat shock protein 70, conserved site; Heat shock protein Hsp70. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during late larval stages, at stages throughout the pupal period. [FlyBase] Observation: Overexpression of the Hsp70 locus (containing Hsp70Bb and Hsp70Bc) in transgenic flies extends lifespan as much as 7.9% [9363888]. Interventions: Assays: Organismal Lifespan Mean: +7.9 Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Note: Hsp70Bb and Hsp70Bc locus overlap. Was original annotated with FBgn0001230 Edit \ Update (Admin) | Delete |
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