|
Symbol: Hsp68 Name: Heat shock protein 68 Entrez gene ID: 42852 Ensembl gene ID: FBgn0001230 Species: Fly (Taxid: 7227) Functional description: Heat shock protein 68; Heat shock protein 68 [Source:FlyBase gene name;Acc:FBgn0001230] [Ensembl]; The gene Heat shock protein 68 is referred to in FlyBase by the symbol Dmel\Hsp68 (CG5436, FBgn0001230). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: unfolded protein binding. There is experimental evidence that it is involved in the biological process: determination of adult lifespan; response to methotrexate; neurogenesis. 10 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Heat shock protein 70; Heat shock protein 70, conserved site; Heat shock protein Hsp70. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during late larval stages, at stages throughout the pupal period. [FlyBase] Observation: Overexpression of Hsp68 extends modestly (by around 15%) median and maximum lifespan [14602080]. Hsp68 is activated by the JNK pathway and target gene of foxo [20976250]. There is a consistent and significant lifespan extension by 20% in both males and females when hsp68 is overexpressed in somatic cells. hsp68 overexpression using GMR-Gal4, and eye-specific driver that expresses Gal4 in salivary glands has no effects. Hsp78 overexpression using the weaker 5961FS driver moderately but significantly extends lifespan [20976250]. Interventions: Assays: Organismal Lifespan Mean: +20 Median: +15 Maximum: +15 Classification: Type: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit