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Symbol: mboa-1 Name: Membrane Bound O-Acyl transferase, MBOAT 1 Entrez gene ID: 181681 Ensembl gene ID: B0395.2 Species: Worm (Taxid: 6239) Functional description: Protein MBOA-1; Protein MBOA-1 [Source:UniProtKB/TrEMBL;Acc:Q17498] [Ensembl]; mboa-1 encodes a putative acyl-Coenzyme A:cholesterol ('sterol') O-acyltransferase, orthologous to human SOAT1 (OMIM:102642); MBOA-1 is required for normal locomotion and normally long lifespan in mass RNAi assays; mboa-1 is expressed in the seam cells and nervous systems of larvae and adults, and in the adult reproductive system. MBOA-1 contains a transmembrane O-acyl transferase (MBOAT) domain. By virtue of its MBOAT domain, MBOA-1 is paralogous to HHAT-1/-2, MOM-1, and MBOA-1 through MBOA-7. [WormBase] Observation: RNA interference of mboa-1 decreases median lifespan by 16% in wild type animals, 28% in a daf-2 background and 12% in daf-2/daf-16 double mutants [18006689]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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