hk

Symbol: hk
Name: hook
Entrez gene ID: 35169
Ensembl gene ID: FBgn0001203
Species: Fly (Taxid: 7227)

Functional description:
Involved in endocytic trafficking by stabilizing organelles of the endocytic pathway. Probably acts as a cytoskeletal linker protein required to tether endosome vesicles to the cytoskeleton. Involved in modulation of endocytosis at stages required for down-regulation of membrane proteins that control synapse size. Not involved in synaptic vesicle recycling. Required in R7 cells for boss endocytosis into multivesicular bodies (MVBs). Has a role in regulating adult longevity. [UniProt]

Observation:

Loss of function mutation in hk decreases mean lifespan by 58 - 60% and maximum lifespan by 15 - 47% [17435236].



Interventions:
  • hk mutation -58 to -60% -15 to -47%

  • Assays: Organismal Lifespan
    Mean: -58 to -60
    Maximum: -15 to -47

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • References:
  • 17435236: Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • HOOK3 (9606)
  • HOOK3 (9598)
  • HOOK3 (9615)
  • HOOK3 (9913)
  • Hook3 (10090)
  • Hook3 (10116)
  • hk (7227)
  • AgaP_AGAP008854 (7165)

  • Inparanoids
  • ENSMUSP00000046788 (10090)
  • ENSRNOP00000012396 (10116)
  • ENSMMUP00000032120 (9544)
  • ENSP00000305699 (9606)

  • Note: GenAge states only a 30% redction of max lifespan.

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