Symbol: hk Name: hook Entrez gene ID: 35169 Ensembl gene ID: FBgn0001203 Species: Fly (Taxid: 7227) Functional description: Involved in endocytic trafficking by stabilizing organelles of the endocytic pathway. Probably acts as a cytoskeletal linker protein required to tether endosome vesicles to the cytoskeleton. Involved in modulation of endocytosis at stages required for down-regulation of membrane proteins that control synapse size. Not involved in synaptic vesicle recycling. Required in R7 cells for boss endocytosis into multivesicular bodies (MVBs). Has a role in regulating adult longevity. [UniProt] Observation: Loss of function mutation in hk decreases mean lifespan by 58 - 60% and maximum lifespan by 15 - 47% [17435236]. Interventions: Assays: Organismal Lifespan Mean: -58 to -60 Maximum: -15 to -47 Classification: References: Aging Relevance Analysis/Source: Homologs Inparanoids Note: GenAge states only a 30% redction of max lifespan. Edit \ Update (Admin) | Delete |
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