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Symbol: GPR1 Name: G-Protein coupled Receptor 1 Entrez gene ID: 851527 Ensembl gene ID: YDL035C Species: Yeast (Taxid: 4932) Functional description: Gpr1p; Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis [Source:SGD;Acc:S000002193] [Ensembl] Observation: Deletion of GRP1 increases mean and maximum replicative lifespan by 41% and 26%, respectively. GRP1 deletion mutants have also longer chronological lifespan. Deletion of GPR1 extends replicative lifespan by reducing cAMP-PKA activity and provides a genetically model for DR [11000115]. Interventions: Assays: Replicative Lifespan Mean: +41 Maximum: +26 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Note: Deletion of GPR1 extends lifespan by aout 50% (Lin et al., 200) arcoding to the Aging Intervention DB. Where does it says that GPR1 deletion extends chronological lifespan? Edit \ Update (Admin) | Delete |
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