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Symbol: gig Name: gigas Alias: CG6975; dTsc2 Entrez gene ID: 40201 Ensembl gene ID: FBgn0005198 Species: Fly (Taxid: 7227) Functional description: gigas; gigas [Source:FlyBase gene name;Acc:FBgn0005198] [Ensembl]; The gene gigas is referred to in FlyBase by the symbol Dmel\gig (CG6975, FBgn0005198). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; kinase binding. There is experimental evidence for 16 unique biological process terms, many of which group under: biological regulation; regulation of biological process; cellular component organization or biogenesis; response to chemical stimulus; response to stress; cellular response to stimulus; signaling; response to DNA damage stimulus; response to nutrient levels; cell-cell signaling; multicellular organismal reproductive process; determination of adult lifespan; primary metabolic process. 51 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system subdivision; external compound sense organ; adult segment; nervous system; adult mesothoracic segment; compound cell cluster organ; peripheral nervous system; eo support cell; rhabdomere; cell cycle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Armadillo-type fold; Rap/ran-GAP; Tuberin; Tuberin, N-terminal; Tuberin-type domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [FlyBase] Observation: Overexpression of gig, also known as dTsc2, results in lifespan extension. Overexpression of dTsc2 increases mean lifespan by 20% and 12%, at 25°C and 29°C, respectively, and protects from deleterious effects of rich food, as if mimicking the effect of DR [15186745]. Overexpression of dTsc2 via a UAS promoter in the eye using the driver gmr-GAL4 or in the nervous system by using appI-GAL4 does not extend the lifespan. Using the drivers 24BGAL4 and PO188-GAL4, enhancer traps that are predominantly expressed in the muscle and fat results in mean lifespan extension of 27% and 37%, respectively, at 29°C [15186745]. Fat-specific drivers DJ634-GAL4 and PO163-GAL4 when used to overexpress dTsc2, also led to a mean lifespan extension of 22% and 31%, respectively, at 29°C [15186745]. Interventions: Assays: Organismal Lifespan Mean: +20 to +31 Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Inparanoids Edit \ Update (Admin) | Delete |
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