Ghrhr

Symbol: Ghrhr
Name: Growth hormone releasing hormone receptor
Entrez gene ID: 14602
Ensembl gene ID: ENSMUSG00000004654
Species: Mouse (Taxid: 10090)

Functional description:
Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. [UniProt]

Observation:

Homozygosity for the Ghrhr(lit) knockout mutation (called little mouse) lowers plasma growth hormone levels, impairs growth and increases lonegevity about 20% [11371619]. Lit homozygous animals are smaller than normal mice [1270792] and their pituitary is defective in growth hormone and prolactin [978118].



Interventions:
  • Ghrhr knockout +20%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • GHRHR (9606)
  • GHRHR (9615)
  • GHRHR (9913)
  • Ghrhr (10090)
  • Ghrhr (10116)
  • GHRHR (9031)
  • ghrhrl (7955)

  • Inparanoids
  • ENSRNOP00000016087 (10116)
  • ENSMUSP00000068120 (10090)
  • ENSMUSP00000068120 (10090)



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