abu-11

Symbol: abu-11
Name: Activated in Blocked Unfolded protein response 11
Entrez gene ID: 173404
Ensembl gene ID: T01D1.6
Species: Worm (Taxid: 6239)

Functional description:
Protein ABU-11; Activated in Blocked Unfolded protein response family member (abu-11) [Source:RefSeq peptide;Acc:NP_493679] [Ensembl]; abu-11 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-11 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-11 may help protect the organism from damage by improperly folded nascent protein. The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Proteins bearing such domains can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. Therefore, it is possible that this gene's protein product undergoes epigenetic control of protein activity, through heritable epigenetic modulation of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. It is important to note that this is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. [WormBase]

Observation:

Overexpression of abu-11 extends mean lifespan by 9% to 28% [16256736].



Interventions:
  • abu-11 overexpression +9 to +28%

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • AgaP_AGAP012386 (7165)
  • Y5H2A.4 (6239)
  • abu-11 (6239)
  • abu-7 (6239)
  • abu-5 (6239)
  • pqn-78 (6239)
  • pqn-57 (6239)
  • abu-9 (6239)
  • M195.2 (6239)
  • abu-8 (6239)
  • M02G9.2 (6239)
  • abu-6 (6239)
  • M02G9.3 (6239)
  • pqn-95 (6239)
  • pqn-76 (6239)
  • pqn-79 (6239)
  • abu-4 (6239)
  • pqn-90 (6239)
  • F07H5.8 (6239)
  • M02G9.1 (6239)
  • pqn-13 (6239)
  • pqn-91 (6239)
  • pqn-2 (6239)
  • pqn-54 (6239)
  • pqn-5 (6239)
  • abu-1 (6239)
  • abu-2 (6239)
  • pqn-16 (6239)
  • pqn-71 (6239)
  • abu-3 (6239)
  • F35A5.4 (6239)
  • abu-10 (6239)



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