g

Symbol: g
Name: garnet
Entrez gene ID: 44819
Ensembl gene ID: FBgn0001087
Species: Fly (Taxid: 7227)

Functional description:
Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes (By similarity). May be a coat protein involved in the formation of specialized structures like pigment granules. [UniProt]

Observation:

Loss-of-function mutation in g reduces mean lifespan by 11 - 42% and maximum lifespan by 7 - 30% [17435236].



Interventions:
  • g mutation -11 to -42% -7 to -30%

  • Assays: Organismal Lifespan
    Mean: -11 to -42
    Maximum: -7 to -30

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Type:
  • Gene
  • Protein coding

    References:
  • 17435236: Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • AP3D1 (9606)
  • AP3D1 (9598)
  • AP3D1 (9615)
  • AP3D1 (9913)
  • Ap3d1 (10090)
  • Ap3d1 (10116)
  • ap3d1 (7955)
  • LOC100329600 (7955)
  • g (7227)
  • AgaP_AGAP000161 (7165)
  • apd-3 (6239)
  • apl5 (4896)
  • APL5 (4932)
  • KLLA0E19405g (28985)
  • AGOS_AFL076W (33169)
  • GeneID:2683401 (148305)
  • NCU04652 (5141)
  • delta-ADR (3702)
  • Os01g0512200 (4530)

  • Inparanoids
  • FBpp0073673 (7227)
  • ENSMUSP00000020420 (10090)
  • ENSRNOP00000025878 (10116)
  • ENSMMUP00000020562 (9544)
  • ENSP00000347416 (9606)
  • YPL195W (4932)
  • SPAC144.06 (4896)



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