Foxm1

Symbol: Foxm1
Name: Forkhead box M1
Entrez gene ID: 14235
Ensembl gene ID: ENSMUSG00000001517
Species: Mouse (Taxid: 10090)

Functional description:
forkhead box M1; forkhead box M1 [Source:MGI Symbol;Acc:MGI:1347487] [Ensembl]

Observation:

Deletion of Foxm1 causes age-related deterioration in liver regeneration. Increased hepatocyte expression in 12-month-old (aged) transgenic mice of Foxm1b alone is sufficient to restore hepatocyte proliferation to levels found in 2-month-old (young) regenerating liver [14647066].



Interventions:
  • Foxm1 deletion
  • Foxm1 overexpression

  • Assays: Organismal Lifespan

    Classification:
  • Aging Associated


  • References:
  • 14647066: Growth hormone stimulates proliferation of old-aged regenerating liver through forkhead box m1b.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • FOXM1 (9606)
  • FOXM1 (9598)
  • FOXM1 (9615)
  • FOXM1 (9913)
  • Foxm1 (10090)
  • Foxm1 (10116)
  • FOXM1 (9031)
  • LOC770007 (9031)
  • LOC768360 (9031)
  • foxm1l (7955)

  • Inparanoids
  • ENSRNOP00000008003 (10116)
  • ENSMUSP00000073041 (10090)
  • ENSMUSP00000073041 (10090)

  • Note: No comment about lifespan. Should maybe excluded from GenAge.

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