FOB1

Symbol: FOB1
Name: FOrk Blocking less 1
Entrez gene ID: 851688
Ensembl gene ID: YDR110W
Species: Yeast (Taxid: 4932)

Functional description:
Fob1p; Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases [Source:SGD;Acc:S000002517] [Ensembl]

Observation:

Mutation in FOB1 extends replicative lifespan by 30-50% [10230397]. FOB1 mutation increases replicative lifespan by 25% in the alpha strain and by 10% in a strain [19030232]. FOB1 mutant exhibit an about 20% mean replicative lifespan increase [15722108]. Deletion of FOB1 causes extension in the short life span of the sir2 mutant by around 50% [10521401]. Mutation of the FOB1 gene slows the generation of rDNA circles and thus extends lifespan by approximately 30% in W303 and 50% in K2307 [10230397]. Even in cells lacking both Sir2 and Fob1, nicotinamide prevents the lifespan extension by DR [16311627].



Interventions:
  • FOB1 deletion

  • Assays: Replicative Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • FOB1 (4932)
  • KLLA0F19140g (28985)
  • AGOS_AGR086C (33169)



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