Denigma: Factor

Fgf23

Symbol: Fgf23
Name: Fibroblast growth factor 23
Alias: Fgf-23
Entrez gene ID: 64654
Ensembl gene ID: ENSMUSG00000000182
Species: Mouse (Taxid: 10090)

Functional description:
Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Upregulates EGR1 expression in the presence of KL. [UniProt]

Observation:

Fgf23 knockouts have a short lifespan and display premature aging-like symptoms including kyphosis, muscle wasting, osteopenia, emphysema, uncoordinated movement, atherosclerosis, and atrophy of the intestinal villi, skin, thymus, and spleen [16436465].

Lack of Fgf23 activities results in extensive premature aging-like features and early mortality of Fgf-23(-/-) mice, while restoring the systemic effects of FGF-23 significantly ameliorates these phenotypes, with the resultant effect being improved growth, restored fertility, and significantly prolonged survival of double mutants [18729070].

Interventions:

Fgf23 knockout

Assays: Organismal Lifespan

Classification:

Aging-Suppressor

Negative Aging-Suppressor

References:

16436465: Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process.

18729070: Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23.

Aging Relevance Analysis/Source:

GenAge