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Symbol: FBP1 Name: Fructose-1,6-BisPhosphatase 1 Alias: ACN8 Entrez gene ID: 851092 Ensembl gene ID: YLR377C Species: Yeast (Taxid: 4932) Functional description: Fbp1p; Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p [Source:SGD;Acc:S000004369] [Ensembl] Observation: Deletion of FBP1 increases survival during the first 15 days during chronologocal aging, but does not increase chronological lifespan. FBP1 deletion reduces production of reactive oxygen species while overexpression of FBP1 shortens chronological lifespan [16199065]. Interventions: Assays: Chronological Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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