C3

Symbol: C3
Name: complement component 3
Alias: ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1
Entrez gene ID: 718
Ensembl gene ID: ENSG00000125730
Species: Human (Taxid: 9606)

Function:
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq, Feb 2009]

Observation:

Genetic variations in C3 are not associated with longevity in Italian [10219002].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • C3F None [10219002]
  • C3S None [10219002]
  • C3SS None [10219002]
  • C3FF None [10219002]
  • C3SF None [10219002]

  • Classification:
  • No Age Effect


  • Type:
  • Gene
  • Protein coding

    References:
  • 10219002: C4, BF, C3 allele distribution and complement activity in healthy aged people and centenarians.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • C3 (9606)
  • C3 (9598)
  • C3 (9615)
  • C3 (9913)
  • C3 (10090)
  • C3 (10116)
  • C3 (9031)
  • c3b (7955)
  • c3c (7955)
  • LOC100331428 (7955)
  • si:dkey-76b14.4 (7955)
  • LOC100331492 (7955)

  • Inparanoids
  • ENSMUSP00000024988 (10090)



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