Name: Nuclear Hormone Receptor family
Entrez gene ID: 172836
Species: Worm (Taxid: 6239)
NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity response of eat-2 mutants and blunts the longevity by bacterial food dilution [Heestand, et al. 2012].
Mutation in nhr-62 suppresses the lifespan extension of eat-2(ad465) animals (p<0.001) [Heestand et al. 2013].
Wild-type (N2) worms with extrachromosomal array dhEx627 (carrying a wild-type nhr-62) exhibit a significant increase in lifespan compared to wild-type (p<0.001) [Heestand et al. 2013].
Assays: Organismal Lifespan
Aging Relevance Analysis/Source:
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