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Symbol: F57B10.3 Entrez gene ID: 172376 Ensembl gene ID: F57B10.3 Species: Worm (Taxid: 6239) Functional description: Protein F57B10.3; Cofactor-independent phosphoglycerate mutase; Protein F57B10.3, isoform a [Source:UniProtKB/TrEMBL;Acc:G5EFZ1] [Ensembl]; F57B10.3 encodes an experimentally confirmed cofactor-independent phosphoglycerate mutase that is essential for embryonic and larval viability, and for normal body morphology; paradoxically, F57B10.3 is also required for normally short livespan (in mass RNAi screens for Age phenotypes); F57B10.3 is expressed widely in larvae and adults, with highest expression in the nerve ring, intestine and body wall muscles; F57B10.3 probably functions in glycolytic and gluconeogenic metabolism. [WormBase] Observation: RNA interference against F57B10.3 extends mean and maximum lifespan by 21% and 48%, respectively, without causing any developmental pleiotropies or defects in mitochondrial morphology. Lifespan extension by F57B10.3 is suppressed by daf-16. F57B10.3 RNAi animals have lower ATP content and oxygen consumption [12447374]. Interventions: Assays: Organismal Lifespan Mean: +23 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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