atp-2

Symbol: atp-2
Name: ATP synthase F1 subunit gamma 2
Entrez gene ID: 175716
Ensembl gene ID: C34E10.6
Species: Worm (Taxid: 6239)

Functional description:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Required during male mating behavior for the response to hermaphrodite contact, acting with lov-1 and pkd-2. May be involved in polycystin signaling. [UniProt]

Observation:

RNA interference of atp-2 results in extended lifespan [12471266]. atp-2 RNAi significantly extends mean lifespan by 14% [11410594].



Interventions:
  • atp-2 RNAi +14%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ATP5B (9606)
  • ATP5B (9598)
  • ATP5B (9615)
  • ATP5B (9913)
  • Atp5b (10090)
  • Atp5b (10116)
  • ATP5B (9031)
  • zgc:111961 (7955)
  • wu:fj55c09 (7955)
  • ATPsyn-beta (7227)
  • AgaP_AGAP012106 (7165)
  • AgaP_AGAP012081 (7165)
  • atp-2 (6239)
  • atp2 (4896)
  • ATP2 (4932)
  • KLLA0D10703g (28985)
  • AGOS_ABR169W (33169)
  • GeneID:2676558 (148305)
  • NCU05430 (5141)
  • AT5G08670 (3702)
  • AT5G08690 (3702)
  • AT5G08680 (3702)
  • Os01g0685800 (4530)
  • Os05g0553000 (4530)
  • PFL1725w (5833)

  • Note: atp-2 is not mentioned in Dillin et al., 2002. Is this a mistake with atp-3?

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